"CollabRx brings to its research partners a unique set of biocomputing tools and services that help transform your genome-wide tumor data into pathways, targets and treatments."

To learn more, please contact our chief scientist, Marty Tenenbaum, at marty@collabrx.com.

Web–based collaborative research platform

The CollabRx platform is a web-based service that enables distributed groups of collaborating scientists to systematically and rapidly explore the opportunity space of targets and leads based on all available knowledge and resources.

Participants interact through web portals that give personalized access to all of the data, knowledge and resources needed to make decisions for  large research projects or for a molecular analysis focused on a single patient.

• Lab scientists plan and conduct experiments, sharing information with one another through web portals.
• Physicians partner with researchers to understand gene expression analyses of tissue samples from individual patients.
• Principal investigators on the scientific advisory board prioritize research opportunities.
• Foundations monitor progress toward strategic goals, and allocate resources in real time.
• Project managers facilitate logistics and track all activities through dashboards and shared work spaces.aces.

The platform connects teams to a rapidly growing ecosystem of academic labs and industrial research services that support every phase of therapy development -- from genomics to clinical trials. The platform manages all of the data, knowledge and materials flowing through this ecosystem to expedite the high-throughput analysis of targets and leads.

All of these powerful capabilities are delivered through a simple web front-end that interfaces seamlessly with current systems.

Specific capabilities and benefits include:

Individualized portals for researchers, clinicians and project managers

• All participants interact with one another and with community resources through personalized portals.
• Researchers use portals to design and run experiments and collaborate on data analysis and interpretation.
• Benefits: Portals facilitate communication, knowledge sharing, collaboration and cross-learning through the research community.

Management dashboards

• Dashboards provide continuous information on the vast array of activities taking place through the research collaborative.
• Project dashboards enable scientists and project managers to monitor and track all the activities of the virtual biotech.
• Foundation dashboards provide tools to prioritize research spending by dynamically allocating resources to the most promising opportunities.
• Benefits: Maximize financial and operational efficiencies.

An ecosystem and catalog of core services and capabilities

• Individual researchers, institutions, and companies can publish information about their core competencies and resources, from clinical trial design to molecular profiling, so that others in the community can readily discover them through the web.
• Benefits: Participating researchers gain unprecedented access to industrial scale, high quality services; Sharing resources leads to centers of excellence

Workflow planning, execution and tracking

• Teams can assemble services into industrial-scale processes, for example:
  
  • Searching repositories for relevant materials,
  • Dispatching them for molecular profiling,
  • Forwarding the data for collaborative analysis of potential targets,
  • And finally contracting for high throughput screens
  • All monitored and tracked with up-to-the-minute precision.
• The best workflows will themselves become part of the ecosystem catalog of services, for others to use and improve.
• Benefits: Automating and sharing best practices and streamlining operations

Federated specimen banking

• Working with experts in specimen banking such as caTIES and caBIG, CollabRx provides easy-to-use interfaces to access specimen banks within the research collaborative.
• Whether participants currently track specimens via a rudimentary spreadsheet or a complex database, CollabRx makes it easy to connect to existing systems.
• Benefits: Access to tissue collected from partner institutions; data points gathered from analyses can be used in future "virtual trials" conducted entirely in silico.

Knowledge management

• The CollabRx platform integrates data and knowledge from public sources including PubMed, ClinicalTrials.gov, scientific search engines (e.g. Microsoft's Medstory and Google Scholar) and databases reporting known regulatory pathways and genomic, proteomic chemical and animal assays.
• We augment public data with knowledge generated by team scientists, and manage the integrated knowledge bases for the research community.
• We organize these data into structured knowledge-bases that support computer reasoning to identify patterns, infer causal connections, and rank opportunities accordingly.
• Benefits: Eliminates redundant experiments; Identifies new emergent opportunities.

Bioinformatics

• In collaboration with academic partners, CollabRx provides cutting-edge computational biology and machine learning services to the research collaborative, including:
  
  • Access to models predicting drug efficacies and side effects,
  • o Analysis of high-throughput genomics and proteomics,
  • Biostatistics for analyzing trials and
  • Algorithms for discovering higher order patterns indicative of potential targets, leads and biomarkers.
• Benefits: Most biologists have limited access to bioinformatics expertise and resources; providing these services adds significant value by optimizing the knowledge derived from all experimental findings.

Management of Research Portfolio

• Finding a cure involves deciding which targets and leads to develop.
• The CollabRx platform provides research portfolio management tools to collaboratively rank the opportunity space of targets and leads.
• Benefits: Accelerate the search for effective therapies and permanent cures.

Please contact us to see a demonstration of the CollabRx web-based collaborative research platform.